He has translated this corpus of work in animals and humans, and established KLFs as key targets of pharmacologic agents. Jain is widely recognized for pioneering studies establishing a family of transcription factors termed Kruppel-like factors (KLF) as nodal determinants of metabolism and immunity, which influences the cardiovascular system. He is also the immediate past president of the American Society for Clinical Investigation (ASCI). Chair & Distinguished Scientist, scientific director of the Harrington Discovery Institute, chief scientific officer at the University Hospitals Health System, and vice dean for Medical Sciences at Case Western Reserve University. Mukesh Jain, MD, is the Ellery Sedgwick Jr. Conversations With Cardiologists: Mukesh Jain, MD
